Table 2 |
||||
|
The major components associated with microfilarial destruction. |
||||
| NATURAL SITUATIONS |
||||
| DERMAL RESPONSES |
||||
| • |
Clinical |
|||
| Pruritus |
||||
| Self-destruction of the skin (mechanical) |
||||
| Development of dermal microabscesses |
||||
| • |
Histopathological |
|||
| Vascular endothelial activation |
||||
| Mast cell increase |
||||
| Blood and tissue eosinophilia |
||||
| Eosinophil adherence to the surface of the microfilariae |
||||
| Macrophage accumulation |
||||
| Fragmentation of microfilariae |
||||
| Local tissue damage (destruction of collagen, etc.) |
||||
| SYSTEMIC EFFECTS |
||||
| • |
Antigen release |
|||
| • |
Organ dysfunction |
|||
| • |
Cytokine circulation |
|||
| DRUG INDUCED SITUATIONS (additional activities): |
||||
| GENERAL (in addition to those activities in Natural Situations) |
||||
| • |
Clinical |
|||
| Migration of microfilariae |
||||
| Increased rate of Mf destruction, |
||||
| More rapid and severe development of the events |
||||
| Progressive movement of the papular response over different parts the body (with low
dose DEC) |
||||
| • |
Histopathological |
|||
| Macrophage ingestion of excess eosinophil-derived material |
||||
| Evidence of immunostimulation |
||||
|
|
||||
|
Mackenzie et al. Filaria Journal 2003 2(Suppl 1):S5 doi:10.1186/1475-2883-2-S1-S5 |
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