Table 1 |
||||
|
Drugs and their activity against Onchocerca volvulus |
||||
| Chemical group |
Effect on O. volvulus |
|||
|
|
||||
| Microfilariae |
Adult worms |
|||
|
|
||||
| Lethal effect |
Lethal effect |
Embryo-Toxicity/depletion |
Embryo-sequestration* |
|
|
|
||||
| Avermectin |
||||
| Mectizan® |
++++ |
0 to ++** |
0 to ++** |
++++ |
| Urea derivative |
||||
| Suramin |
+++ |
++++ |
++++ |
0 |
| Piperazine derivative |
||||
| Diethylcarbamazine |
++++ |
0 |
0 |
0 |
| Organophosphate |
||||
| Metrifonate |
+++ |
0 |
0 |
0 |
| Benzimidazole carbamate |
||||
| Mebendazole |
++ |
0 |
++ |
0 |
| Flubendazole |
0 |
0 |
++ |
0 |
| Albendazole |
0 |
0 |
+++ |
0 |
| Thiourea |
||||
| Amocarzine† |
+++ |
0 |
0 |
0 |
| Tetracycline |
||||
| Doxycycline‡ |
0 |
0 |
++++ |
0 |
|
|
||||
|
* A block to the release of microfilariae is the primary effect, followed by their degeneration in utero ** On multiple dosage † Not registered ‡ Experimental drug |
||||
|
Awadzi Filaria Journal 2003 2(Suppl 1):S6 doi:10.1186/1475-2883-2-S1-S6 |
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