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Nodule counts (including all removed nodules at 24 mpt), diameter (means ± standard deviations) and median age scores of female worms before and 24 months after the start of treatment in cattle, following 7 monthly treatments with ivermectin 500 μg/kg subcutaneously, doramectin 500 μg/kg subcutaneously or no treatment. Nodule numbers were adjusted for nodules removed for assay. (the number of animals in each group, n = 3 except ‡ n = 2; number of nodules per group, n = 6 except * where n = 4). |
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| Timepoint |
0 mpt |
24 mpt |
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|
|
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| count1 |
Diameter2 (mm) |
♀age score3 |
count |
Diameter (mm) |
♀age score |
|
| Control |
75 ± 26 |
5.9 ± 0.6 |
1.5 |
61 ± 25 ‡ |
6.7 ± 0.7* |
2* |
| Ivermectin |
73 ± 25 |
7.4 ± 1.2 |
1 |
72 ± 19 |
6.5 ± 0.4 |
3 |
| Doramectin |
73 ± 35 |
6.9 ± 1.1 |
2 |
66 ± 36 |
6.9 ± 0.9 |
3 |
|
1 Two-way ANOVA: effect of interaction of treatment and mpt p = 0.630; effect of treatment p = 0.891; effect of mpt p = 0.510 2 Two-way ANOVA: effect of interaction of treatment and mpt p = 0.270;effect of treatment p = 0.403; effect of mpt p = 0.996 3 Not tested statistically | ||||||
deC Bronsvoort et al. Filaria Journal 2005 4:8 doi:10.1186/1475-2883-4-8 |
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