Table 1 

Quantification of several key biological parameters in the EPIFIL and LYMFASIM model variants for Pondicherry, where Wuchereria bancrofti is transmitted by Culex quinquefasciatus. Values in boldface were estimated indirectly by fitting the model outcomes to observed epidemiological data; other values were quantified directly from literature, theory, and analysis of local data 

Parameter 
EPIFIL 
LYMFASIM 



AntiL3 immunity 
Antifecundity immunity 



Parasite lifecycle 

Average adult worm life span in years 
8 ^{a} 
10.2 ^{b} 
11.8 ^{b} 
Average mf life span in months 
10 ^{a} 
10 ^{c} 
10 ^{c} 
Premature period in months 
 
8 
8 
Exposure variation by age 

Exposure at age zero as fraction of maximum exposure 
0 
0.26 
0.40 
Age in years at which maximum exposure is achieved 
9 
19.1 
21.3 
Density dependence in mosquitoes 

Maximum number of L3 larvae that can develop in mosquitoes at high mf intensities 
6 ^{d} 
6.6 ^{e} 
6.6 ^{e} 
Acquired immunity 

Duration of acquired immunity in years 
lifelong 
9.6 ^{f} 
11.2 ^{f} 
Other parameters 

Monthly biting rate 
5760 
2200 
2200 
Proportion of L3 larvae in mosquitoes that enters the human host when a mosquito bites 
0.414*0.32 = 0.13 
0.1 
0.1 
Proportion of inoculated L3 larvae that develops successfully into adult worms (x10^{3}) 
0.113 
1.03 ^{g} 
0.42 
Mf production per worm 
2 
0.61 ^{h} 
4.03 ^{h, i} 


 Not considered in the model; mf, microfilaria. ^{a }Assuming an exponential distribution. ^{b }Assuming a Weibull distribution with shape parameter α = 2. ^{c }Assuming an exponential distribution, approximated with discrete time steps. ^{d }Exponential saturating function with initial increase from zero = 0.047. ^{e }Hyperbolic saturating function with initial increase from zero = 0.09. ^{f }Period in which the strength of the immune response is halved in the absence of boosting. ^{g }In the absence of antiL3 immunity. ^{h }In the presence of at least 1 male worm, scaled to the number of mf per 20 μl peripheral blood. ^{i }In the absence of antifecundity immunity. 

Stolk et al. Filaria Journal 2006 5:5 doi:10.1186/1475288355 