Table 2

LYMFASIM predictions of the number of annual mass drug treatment rounds required to achieve elimination in an area like Pondicherry, with 99% probability. Results are shown for four different drugs or drug combinations and two coverage levels. Predictions are based on the anti-L3 variant of the model for Pondicherry, with a precontrol microfilaraemia prevalence of 8.5%. Elimination is defined as zero microfilaraemia prevalence 40 years after the start of treatment. Source: [31]

Assumed treatment effects (proportion killed)

Predicted number of rounds for elimination, with coverage

Drug(s)

adult worms

microfilariae

65%

80%

Ivermectin + albendazole

35%

100%

10

6

Diethylcarbamazine

50%

70%

8

5

Diethylcarbamazine + albendazole

65%

70%

6

4

Doxycycline

80%

0%

6

4

Stolk et al. Filaria Journal 2006 5:5   doi:10.1186/1475-2883-5-5