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Physical disability and psychosocial impact due to chronic filarial lymphoedema in Sri Lanka

RS Wijesinghe1*, AR Wickremasinghe2, Sriyani Ekanayake1 and MSA Perera3

Author Affiliations

1 Department of Parasitology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka

2 Department of Community Medicine, Faculty of Medicine, University of Kelaniya, P.O. Box 6, Thalagolla Road, Ragama, Sri Lanka

3 Department of Family Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka

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Filaria Journal 2007, 6:4  doi:10.1186/1475-2883-6-4


The electronic version of this article is the complete one and can be found online at: http://www.filariajournal.com/content/6/1/4


Received:25 September 2006
Accepted:29 March 2007
Published:29 March 2007

© 2007 Wijesinghe et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

Information on the physical and psychosocial disability of lymphatic filariasis in Sri Lanka is scarce. Therefore this study was carried out to describe the physical disability and psychosocial impact associated with chronic lymphoedema in patients attending filariasis clinics in the Colombo district, Sri Lanka.

Methods

Four hundred and thirteen patients with lymphoedema of limbs attending filariasis clinics in Werahera and Dehiwala in the Colombo district were enrolled in the study after obtaining informed written consent. Data were collected using a pre-tested, interviewer-administered questionnaire and analyzed using SPSS.

Results

Majority (95%) of patients had lower limbs affected and there was a significant association with difficulty in walking (p = 0.023). The swollen limb affected the work of 87 (52 %) of employed patients and 26 persons reported loss of job. Approximately 25 % and 6 % reported having problems interacting with the community and family, respectively and 8.7 % felt that they were rejected by society. The swollen limb was perceived as a major problem by 36.8 % of patients. Of the married persons, 5.7 % and 6.2 % reported sexual and marital problems respectively, due to their swollen limb/s. Of those who had marital problems, 77.3% reported sexual problems as well (p < 0.001).

Conclusion

Lymphoedema significantly affects physical, psychological and social functioning in affected individuals. Morbidity control, in addition to control of physical disability, should target the psychosocial consequences.

Background

Lymphatic filariasis (LF) is an important public health and socio-economic problem worldwide. It affects 120 million people in over 80 countries [1], of which, about 14 million suffer from lymphoedema or elephantiasis of legs [2]. The disease is prevalent in urban and rural areas affecting people of all ages and both sexes, particularly those of low socioeconomic status [3].

Although LF does not cause immediate mortality, the associated severe morbidity has resulted in it being recognized as the second leading cause of disability worldwide [4]. The two most common chronic manifestations of the disease – hydrocoele and lymphoedema cause socio-psychological problems to patients and their families [5]. Chronic disease is debilitating, leading to a restriction in the duration and capacity to work and to changes in activity patterns [6,7].

As morbidity management of individuals already affected by LF is an important component of the Global Programme for Elimination of Lymphatic Filariasis [8], it is important to understand the extent of the physical, psychological and social disability caused by the disease. Studies done in India and Ghana have demonstrated the functional impairment, disability [9], economic burden [10-12] and psychosocial burden [13,14] caused by chronic filarial lymphoedema on affected individuals, their families and communities.

In Sri Lanka, more than half the population, approximately 9.8 million people, live in the filariasis endemic area, which covers eight of the 25 districts of the country (T.S. Liyanage, unpublished observation). Information on the physical and psychosocial disability of filariasis in Sri Lanka is scarce. A study done in the south of Sri Lanka [15] revealed some of the socio – psychological problems experienced by lymphoedema patients. In this study, we have attempted to describe and quantify the physical and psychosocial disability caused by chronic filarial lymphoedema in the Colombo district in Sri Lanka.

Methods

Study area

The study was carried out in two of the three filariasis clinics conducted in the Colombo district by the national Anti-Filariasis Campaign. The commercial capital of Sri Lanka, Colombo, is located in this district, which is an area endemic for bancroftian filariasis. These filariasis clinics provide services to the people for screening and management of filariasis for both first contact care and referrals.

Study design

A cross sectional descriptive study was carried out between April 2004 and February 2005 in the filariasis clinics at Werahera and Dehiwala in the Colombo district. Most of the clinic attendees of these two clinics had been referred by General Practioners (GPs), consultants or government hospitals after treating them for varying periods ranging from months to years with repeated courses of diethylcarbamazine citrate (DEC). Some patients had come direct for first contact care while others were self-referrals following treatment failures.

Lymphoedema was diagnosed clinically as persistent oedema of more than 6 weeks duration. Four hundred and thirteen patients were enrolled after obtaining informed written consent. Inclusion criteria were, patients should be above 5 years of age, attending the above filariasis clinics and have clinically detectable, persistent oedema of more than 6 weeks duration. Exclusion criteria included patients with bilateral leg involvement in whom other causes of oedema (eg: cardiac, renal, hepatic causes) had not been excluded and patients unable to understand/answer questions asked in questionnaire e.g.: mentally unstable patients. All patients selected were enrolled in the study except two patients with Down's Syndrome who were excluded from the study. In all patients with bilateral leg involvement other causes of oedema had already been excluded.

Study instrument

As standard questionnaires to measure psychological impact of chronic lymphoedema have not been validated for Sri Lanka, a questionnaire was developed by a group of experts including a psychologist, a psychiatrist, a sociologist and a public health specialist. Face validity was assessed by an independent group who considered the questionnaire to be able to detect psychological impact. The questionnaire was developed to obtain information on demographic characteristics, disabilities (activities of daily living and impact on occupation, education, attending social gatherings, religious activities, leisure activities), social implications (interactions with family, friends, work mates, community), feelings regarding illness and marital and sexual problems. The questionnaire was pre-tested. The principal investigator and two trained medical officers administered the questionnaire.

The level of lymphoedema was graded according to standard criteria [16]:

Grade 1 – oedema spontaneously reversible on elevation

Grade II – oedema not spontaneously reversible on elevation, skin not thickened

Grade III – oedema not spontaneously reversible on elevation, skin thickened

Grade IV – oedema not spontaneously reversible on elevation, skin thickened with warty/nodular, papillomatous growths.

Data analysis

Data analysis was done using SPSS version 10.0 of the SPSS software package (SPSS Inc, Chicago, IL). Frequency distributions were obtained and associations tested using the chi square test and t-tests.

Ethical considerations

Ethical clearance for the study was obtained from the Ethical Review Committee of the Faculty of Medical Sciences, University of Sri Jayewardenepura, Sri Lanka.

All patients were treated for filariasis and associated problems and necessary referrals done when indicated. They were educated regarding the morbidity control measures advocated in the Community Home Based Care programme [2] and were followed up one year later.

Results

Profile of patients

The majority of patients were female (72.4%) and married (85.5%) (Table 1). The mean age of the patients was 51.27 years (SD = 13.58), ranging from 9 to 85 years. The majority of patients (n = 357, 86.4%) with lymphoedema were over 35 years of age (Table 2). Most females (64.2%) were housewives, while the majority of males (77.2%) were employed. Overall, 40.4% (n = 167) of the study sample was employed in paid jobs. Of those who were willing to reveal their income (n = 159), almost 40% were earning a monthly income of less than Rs. 5000 (≅ USD 50). The majority (65.6%) had studied up to grades 6–11.

Table 1. Profile of patients

Table 2. Distribution of lymphoedema in age groups

Characteristics of lymphoedema

The duration of lymphoedema in a limb varied from 5.27 to 11.64 years with the longest duration being 50 years. The left (59.3 %) and right (50.8%) lower limbs were the most frequently affected (Table 1). Eighty one patients had lymphoedema of more than one limb. The majority of the limbs with lymphoedema (49.6 %) were of Grade II and Grade 1 (41.2%).

Impact on activities of daily living

Approximately 37% reported difficulty in walking (Table 3) and this was significantly associated with lower limb oedema (p = 0.023) as compared to patients without lower limb oedema. Almost 30 % reported difficulty in doing housework due to the swollen limbs, but this was not significantly associated with lower limb or upper limb oedema. The maximum grade of lymphoedema was significantly associated with difficulty in standing (p = 0.008) and using the toilet (p = 0.005). Although not significant, more patients with grades III and IV lymphoedema found it difficult to bathe than patients with lower grades of lymphoedema.

Table 3. Impact of lymphoedema on activities of daily living

The other activities that patients reported difficulty in performing were, climbing stairs, walking uphill, drawing water from well, getting into a bus, holding railing in a bus, sitting and lifting heavy objects

Interference with selected activities

All students interviewed in this study reported that the lymphoedema interfered with their education (Table 4). This was mainly due to the patients feeling that their fellow students rejected them (less friendly/isolated/no spontaneous invitation to join in group activities), resulting in them not following classes regularly. An affected medical student reported difficulty in standing for prolonged periods during ward work.

Table 4. Psychosocial impact of lymphoedema

Of the 167 employed patients, more than half (n = 87, 52.1%) reported interference with their occupation due to the swollen limb/s. This was in the form of loss of work time, inability to do heavy work, stigmatization, being penalized by supervisors and co-workers and being given less overtime work. Twenty six patients, comprising 12.3% of those currently employed, unemployed and retired, claimed they lost their jobs due to the lymphoedema. Most of those who had lost jobs were labourers doing heavy work, but also included a photographer and an artist who had to give up their professions due to upper limb swelling and an army personal who had to give up active combat due to lower limb swelling. The majority of those who lost their jobs were married (69.2%), males (61.5%) with almost 20 % (of those who stated an income) previously having earned a monthly income of less than SL Rs. 5000 (≅ USD 50).

The lymphoedema also interfered with religious activities in 16 % of affected patients with more impairment in higher grades of lymphoedema (p = 0.005). This was due to inability to squat to worship in Buddhist temples, as well as being reluctant to go to places of worship for fear of others noticing their swollen limb.

Leisure activities such as sports and other recreational activities were also affected due to the physical difficulty in doing such activity as well as feeling shy to interact with peers. Although not significant, a greater percentage of patients with grade IV lymphoedema had interference with leisure activities and occupation than patients with lower grades of lymphoedema.

Interactions with society

Twenty five percent of the patients found it difficult to get along with the community (Table 4) and 36 (8.7%) felt they were totally rejected by society (laughed at, not included in social activities, isolated). Even within their own families, 24 (5.8%) patients had problems interacting with them.

Patients' feelings regarding the swollen limbs

Almost 60 % (n = 246) of the patients perceived their swollen limbs as being a problem affecting their lives and had varying feelings regarding it (Table 4). Twenty one (8.5%) patients reported feelings of depression, of whom five had past suicidal thoughts. The other feelings/concerns expressed were inconvenience in always having to wear long garments to hide the swollen lower limbs, inability to wear normal foot wear, feeling of being a burden to the family, fear of transmitting disease to family, inability to do a job, intense fear of being rejected by society, worried about not being able to get married due to the swollen limb and that their whole life changed due to the illness. Fifty two (12.6%) patients (12% of females and 14 % of males) reported feeling lonely and isolated because of the swollen limb.

Marital and sexual problems

Of the 353 married patients, 20 (5.7%) and 22 (6.2%) reported sexual and marital problems respectively, which they attributed to their swollen limbs. Sexual problems were inquired only from married individuals due to cultural reasons. More females than males reported these problems (female: male ratio of sexual problems was 12:8 and marital problems was 17: 5) although this was not statistically significant (p = 0.333 and p = 0.562 respectively). Among married persons, sexual problems were significantly associated with marital problems, with 77% of those who reported marital problems also having sexual problems (p < 0.001).

The marital problems varied from the spouse nagging and being unsupportive towards treatment to totally rejecting and avoiding all physical contact with the patient. Three patients reported that their husbands had left them for other women due to this problem.

Discussion

Lymphatic filariasis causes disability due to its acute manifestations as well as its chronic forms. Unlike the physical disabilities that are visible, the psychosocial disabilities caused by LF tend to be unrecognized [14]. There is growing interest in the role of mental and social health in promoting positive health and good quality of life [14]. Previous studies have shown that LF causes severe disability and considerable treatment costs due to acute and chronic disease in India [5,9,10,13,17,18] and Ghana [12]. Such information is scarce in Sri Lanka.

It has been shown that medical experts assigned lower severity levels to patients' physical and psychosocial disability than the sufferers, indicating that experts are able to perceive the extent of disability to a certain extent only [14]. As only patients can assess the exact extent of disability, their perceptions are important in planning and implementing morbidity control programmes for LF [14]. This study demonstrates the significant physical disability and psychosocial problems as perceived by patients affected by chronic filarial lymphoedema in an endemic urban area of Sri Lanka.

Difficulties were reported in all activities inquired about, mostly in walking which was significantly associated with lower limb oedema and also in carrying out household chores. Similar results have been reported from rural India, where domestic activities of affected females were seen to be impaired due to chronic and/or acute manifestations of the disease [5,7,9,17,18]. Many patients in our study population were using toilets of the squatting type, which posed problems for many of them, with two patients not being able to use the toilet at all without help from others.

These physical difficulties arose in spite of the majority of patients interviewed suffering from a relatively early stage of lymphoedema of Grade II, which shows that even at lower grades, lymphoedema causes physical disability. The higher the grades of lymphoedema, the difficulty in doing activities such as standing, using the toilet and bathing were more. Therefore, it is important to manage the lymphoedema at very early stages, preferably at grade I, to prevent progression and increase of disability.

Lymphoedema affected the occupation in more than half the patients in our study. Twenty six patients had completely lost or left their jobs, the majority of them being married males, the sole breadwinners of the family, who worked as labourers doing heavy work and earning less than SL Rs. 5000 (USD 50) a month. Therefore losing that small source of income would have clearly had a very significant social impact on the affected patients' families. A greater percentage of patients with grade IV lymphoedema had interference with their occupational activities than patients with lower grades of lymphoedema, which is to be expected. In India too, several studies have reported similar occupational interferences and loss of jobs due to the chronic lymphoedema as well as recurrent acute adenolymphangitis attacks (ADL attacks) [7,9,13,14,17]. Loss of work time in chronic patients, unlike in the acute manifestations, is perpetual as the chronic disease manifestations are mostly irreversible [5].

The impact on social activities such as attending social gatherings and leisure activities as seen in our study were more in higher grades of lymphoedema. This trend is to be expected as the more severe the lymphoedema is, the more the accompanying complications and disability.

Almost one fourth of patients had problems interacting with the community. This resulted in patients, especially those with advanced stages of lymphoedema/elephantiasis, becoming isolated and withdrawn from society, avoiding social gatherings and activities and becoming angry, bitter and depressed about their situation. Even within their own families, about 6 % reported problems arising due to their swollen limbs.

Similar results were reported from the Gampaha district of Sri Lanka [19], where 18.2% of patients experienced feelings of being rejected by society. In India too, chronic brugian filariasis prevented people from gaining a standing in the community including claims that they did not receive any support from their community [13].

Approximately 37% of patients in this study felt the swollen limb was a major problem affecting their lives, causing shyness, depression and intense worry about progression of disease to elephantiasis. A few had been suicidal as well at some point of their disease. Similar negative feelings have been reported in studies done in other areas of Sri Lanka [15,19], India [13,14] and Ghana [20].

Approximately six percent of married persons experienced sexual and marital problems with the cause of the marital problems probably being sexual problems arising due to the swollen limb/s (p < 0.001). The patients view was that these problems were either solely or mainly due to their swollen limb/s. It was seen that more females than males reported marital and sexual problems in our study. This was not surprising as males are generally less reluctant to admit and discuss their problems, while females are more responsive towards admitting these issues and discussing them. Similar problems such as unsuitability for marriage, sexual dysfunction and divorce attributed to the lymphoedema have been reported in a study in Ghana [20].

Apart from the chronic effects, acute ADL attacks too cause temporary but severe disability in patients [14]. Eighty three percent of acute episodes occur in chronic patients [21]. We specifically do not address these issues in this manuscript. Therefore, if acute manifestations were also considered, the disability and impact of chronic lymphoedema would be much greater than what is highlighted here.

Due to the fact that the disabling psycho-social impact of chronic lymphoedema often go unnoticed, more emphasis is given to treating the patient's visible physical problems, often resulting in irrational continuous prescription of anti filariasis drugs. This was clearly seen in our study population, the majority of whom were treated with DEC for very long periods of time, the maximum being 43 years.

The study was conducted in the Colombo district, the district having the best educational and health facilities and over 90% of the population being literate. In spite of this educational background, many patients are stigmatized and penalized even in relatively enlightened communities.

The WHO recommended morbidity control strategy in the form of a Community Home Based Care (CHBC) programme is still in its infancy in Sri Lanka. The CHBC programme deals with alleviating the physical disability of already affected patients by motivating and training patients and their carers to adhere to simple, yet effective strategies involving the affected areas – washing, elevation, prevention and treating entry lesions and using foot wear [2]. While fully appreciating the importance of this and further reiterating the importance of focusing on new strategies in the management of lymphoedema to alleviate physical morbidity, we strongly recommend that the psychosocial problems of patients be addressed at the same time, adopting a holistic approach. Counselling, formation of support groups and rehabilitation of affected patients should be done. Finding them less strenuous, preferably home based jobs would reduce patients' economic problems and give them self-confidence and a feeling of independence and worth. The community should be educated on the cause and transmission of the disease to dispel misconceptions, myths and stigma attached to the disease. The patients too should be educated to adjust to the effects of the illness and treatment.

We were unable to examine patients for genital manifestations in the clinic setting, which did not provide adequate privacy to patients. We acknowledge this to be a major limitation of this study as genital manifestations causes sexual disability in affected patients. [22].

These results would be a useful guide to design a morbidity control programme suited to the Sri Lankan community. Family members should be trained and involved in these morbidity management programmes, especially the CHBC, to reduce the physical disability directly and accompanying psychosocial disability indirectly.

Conclusion

A significant proportion of patients with chronic filarial lymphoedema in the Colombo district in Sri Lanka suffer some form of physical disability, psychological and/or social consequences due to the illness, despite having been treated conventionally with long term DEC. The management of chronic lymphoedema should include measures to alleviate the psychosocial problems as well as the physical morbidity of affected patients.

Abbreviations

ADL: Adenolymphangitis

LF: Lymphatic filariasis

GP: General Practioners

DEC: diethylcarbamazine citrate

SL Rs: Sri Lankan rupees

USD: US Dollar

CHBC: Community Home Based Care

Competing interests

The author(s) declare that they have no competing interests.

Authors' contributions

RW conceived and designed the study, collected data, analyzed and interpreted data and drafted the manuscript.

ARW analyzed and interpreted data, supervised drafting of manuscript and revised manuscript critically for intellectual content.

SE conceived, designed and supervised the study and revised manuscript critically for intellectual content.

MSAP supervised the study and revised manuscript critically for intellectual content.

All authors read and approved the final manuscript.

Acknowledgements

Funding by the University of Sri Jayewardenepura Research Grant ASP/6/RE/2004/05 is acknowledged. We also acknowledge Dr. T. Liyanage, Director, Anti-Filariasis Campaign, Sri Lanka for giving us permission to carry out the study, Professors Mirani Weerasooriya and S. Sivayogan for expert advice, the medical officers who helped in administering the questionnaire and the staff and patients of the filariasis clinics in Dehiwala and Werahera.

References

  1. World health Organization: Preparing and Implementing a National Plan to Eliminate Lymphatic Filariasis. In WHO/CDS/CPE/CEEE/2000.15. WHO, Geneva; 2000. OpenURL

  2. Dreyer G, Addiss D, Dreyer P, Noroes J: Basic Lymphoedema Management: Treatment and Prevention of Problems Associated with Lymphatic Filariasis. 1st edition. New Hampshire, Hollis; 2002. OpenURL

  3. Crompton DWT, Montresor A, Nesheim NC, Savioli L: Controlling disease due to helminth infections. World Health Organization, Geneva; 2003.

  4. World Health Organization: Bridging the Gap. In The World Health Report, 1995. Geneva: WHO; 1995. OpenURL

  5. Ramaiah KD, Guyatt H, Ramu K, Vanamail P, Pani SP, Das PK: Treatment costs and loss of work time to individuals with chronic lymphatic filariasis in rural communities in south India.

    Tropical Medicine and International Health 1999, 4:19-25. Publisher Full Text OpenURL

  6. Evans DB, Gelband H, Vlassoff C: Social and economic factors and the control of lymphatic filariasis: a review.

    Acta Tropica 1993, 53:1-26. PubMed Abstract | Publisher Full Text OpenURL

  7. Ramaiah KD, Radhamani MP, John KR, Evans DB, Guyatt H, Joseph A, Datta M, Vanamail P: The impact of lymphatic filariasis on labour inputs in southern India: results of a multi-site study.

    Annals of Tropical -Medicine and Parasitology 2000, 94:353-364. OpenURL

  8. Shenoy RK: Management of disability in lymphatic filariasis – an update.

    Journal of Communicable Diseases 2002, 34:1-14. PubMed Abstract OpenURL

  9. Ramaiah KD, Vijay Kumar KN, Ramu K, Pani SP, Das PK: Functional impairment caused by lymphatic filariasis in rural area of south India.

    Tropical Medicine and International Health 1997, 2:832-838. Publisher Full Text OpenURL

  10. Ramaiah KD, Das PK, Michael E, Guyatt H: The economic burden of lymphatic filariasis in India.

    Parasitology Today 2000, 16:251-253. PubMed Abstract | Publisher Full Text OpenURL

  11. Ramu K, Ramaiah KD, Guyatt H, Evans DB: Impact of lymphatic filariasis on the productivity of male weavers in a south Indian village.

    Transactions Of The Royal Society Of Tropical Medicine and Hygiene 1996, 90:669-670. Publisher Full Text OpenURL

  12. Gyapong JO, Gyapong M, Evans DB, Aikins MK, Adjei S: The economic burden of lymphatic filariasis in northern Ghana.

    Annals of Tropical Medicine and Parasitology 1996, 90:39-48. OpenURL

  13. Suma TK, Shenoy RK, Kumaraswami V: A qualitative study of the perceptions, practices and socio-psychological suffering related to chronic brugian filariasis in Kerala, southern India.

    Annals of Tropical Medicine and Parasitology 2003, 97:839-845. Publisher Full Text OpenURL

  14. Krishna Kumari A, Harichandrakumar KT, Das LK, Krishnamoorthy K: Physical and psychosocial burden due to lymphatic filariasis as perceived by patients and medical experts.

    Tropical Medicine and International Health 2005, 10:567-573. Publisher Full Text OpenURL

  15. Yahathugoda TC, Wickramasinghe D, Weerasooriya MV, Samarawickrama WA: Lymphoedema and its management in cases of lymphatic filariasis: the current situation in three suburbs of Matara, Sri Lanka, before the introduction of a morbidity- control programme.

    Annals of Tropical Medicine and Parasitology 2005, 99:501-10. Publisher Full Text OpenURL

  16. World Health Organization: Informal Consultation on Evaluation of Morbidity in Lymphatic Filariasis. In Document WHO/TDR/FIL/92.3. Geneva: WHO; 1992. OpenURL

  17. Ramaiah KD, Ramu K, Guyatt H, Vijay Kumar KN, Pani SP: Direct and indirect costs of acute form of lymphatic filariasis in rural areas in Tamil Nadu, south India.

    Tropical Medicine and International Health 1998, 3:108-115. Publisher Full Text OpenURL

  18. Babu BV, Nayak AN: Treatment costs and work time loss due to episodic adenolymphangitis in lymphatic filariasis patients in rural communities of Orissa, India.

    Tropical Medicine and International Health 2003, 8:1102-1109. Publisher Full Text OpenURL

  19. Chandrasena TGAN, Premaratne R, de Silva NR: Lymphoedema management, knowledge and practices among patients attending filariasis morbidity control clinics in Gampaha District, Sri Lanka.

    Filaria Journal 2004, 3(6):1-6. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  20. Ahorlu CK, Dunyo SK, Koram KA, Nkrumah FK, Agaard-Hansen J, Simonsen PE: Lymphatic filariasis related perceptions and practices on the coast of Ghana: implications for prevention and control.

    Acta Tropica 1999, 73:251-264. PubMed Abstract | Publisher Full Text OpenURL

  21. Ramaiah KD, Ramu K, Vijay Kumar KN, Guyatt H: Epidemiology of acute filarial episodes caused by Wucheraria bancrofti infection in two rural villages in Tamil Nadu, south India.

    Transactions Of The Royal Society Of Tropical Medicine and Hygiene 1996, 90:639-643. Publisher Full Text OpenURL

  22. Dreyer G, Noroes J, Addiss D: The silent burden of sexual disability associated with lymphatic filariasis.

    Acta Tropica 1997, 63:57-60. PubMed Abstract | Publisher Full Text OpenURL