Evaluation of a recombinant parasite antigen for the diagnosis of lymphatic filariasis.
Dissanayake S, Zheng H, Dreyer G, Xu M, Watawana L, Cheng G, Wang S, Morin P, Deng B, Kurniawan L, et al.
Department of Tropical Public Health, Harvard School of Public Health, Boston, Massachusetts.
We evaluated the usefulness of a recombinant parasite antigen (recSXP1) for the serologic diagnosis of lymphatic filariasis. A large proportion of sera from microfilaremic donors living in five different endemic countries (356 of 446 [80%]) contained IgG antibodies to recSXP1, as do sera from approximately 33% of amicrofilaremic patients with acute filarial disease and/or indirect evidence of active filarial infection. Exposure to filarial worms per se does not appear sufficient to elicit an anti-SXP1 antibody response. Thus, this serologic test identifies a large proportion of persons with active lymphatic filariasis among residents of endemic areas.
Publication Types:
PMID: 8024066 [PubMed - indexed for MEDLINE]